Neuroprotective Impact Of Zingerone And Gramine On Scopolamine-Induced Amnesia Model

Progressive memory loss is a symptom of many dangerous neurological diseases, such as Alzheimer's disease and forgetfulness. The goal this study was to see how well bioactive molecules worked in animal models amnesia caused by scopolamine. Ginger has lot Zingerone (Zn), which makes up about 9.25% the total amount. Gramine (Ga) nonterpenoid indole alkaloid that found plants like barley wheat. It also known donaxine. Acute toxicity tests were done on both drugs. As an model for scopolamine induced rat selected behavioural evaluation Morris water maze (MWM) elevated plus used measure changes (EPM). In case biochemical glutathione (GSH), lipid peroxidation (LPO), catalase (CAT), AchE serum levels performed. Histopathological imaging animals administered per following grouping Zn (75,125,250 mg/kg p.o.) Ga (13, 27.5,55 mg/kg), standard donepezil (1 p. o.) This Zn, Donepezil reading demonstrate significant improvement antioxidant defence reversed (LPO, GSH), enzymatic (AchE) observed MWM EPM compared Positive control so above observation significantly fixed problems based discussion, drugs may be able fight Alzheimer's.